Vortrag von Dr. Friederike Adams
02. Februar 2026, um 16:30 Uhr im Hörsaal ZAF
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Meldung vom:
EINLADUNG
Am Montag, 02. Februar 2026, um 16:30 Uhr im Hörsaal ZAF (Philosophenweg 7, 07743 Jena) hält Dr. Friederike Adams (Institute of Polymer Chemistry, Universität Stuttgart) einen Vortrag zum Thema:
„Precision Nanocarriers for Ocular Therapies“
Alle Interessenten sind herzlich eingeladen!
Curriculum Vitae
04/2011 - 08/2013 Bachelor of Science in Chemistry at Technical University of Munich (TUM), Germany.
10/2013 – 06/2015 Master of Science in Chemistry at Technical University of Munich (Main subject: Organic Chemistry; Minor subject: Chemistry of Macromolecules, Colloids and Interfaces), Germany. Master thesis on Rare Earth Metal-Mediated Group-Transfer Polymerization supervised by Prof. B. Rieger.
08/2015 – 01/2019 PhD-thesis funded by the Bavarian Stateministry of Environment and Consumer Protection, Technical University of Munich, Group of Prof. B. Rieger, Germany. Title: From Michael-type systems to biobased lactones: Designing novel polymer microstructures with modified bis(phenolate)lanthanides.
11/2018 – 07/2021 Postdoctoral researcher at Ludwig-Maximilians-University Munich, Group of Prof. O. Merkel, Germany. Subject: Design and evaluation of amphiphilic polymers in nanomedicine.
11/2020 - 04/2021 Honorary research fellow funded by the German Academic Exchange Service at University of Warwick, Group of Prof. D. Haddleton, UK. Subject: Synthesis of spermine-based polymers via living-radical polymerization.
Since 07/2021 Independent junior research group leader, University of Stuttgart and University of Tübingen, Germany. Funded by the Federal Ministry of Education and Research (BMBF) and the Baden-Württemberg Ministry of Science as part of the Excellence Strategy of the German Federal and State Governments.
Since 04/2025 Deputy Professor, Chair of Macromolecular Chemistry, Technical University of Munich https://www.ch.nat.tum.de/makro/startseite/Externer Link
Quelle: https://www.ipoc.uni-stuttgart.de/ppp/team/Adams-00001/Externer Link
Precision Nanocarriers for Ocular Therapies
Versatile organic synthetic routes enable the design of functional polymers with precisely tailored architectures for advanced therapeutic applications. In ophthalmology, the delivery of both nucleic acids and hydrophobic small-molecule drugs remains particularly challenging due to complex ocular barriers and the limited ability of conventional formulations to cross these barriers efficiently.
This talk introduces polymer-based nanocarriers designed for ocular drug delivery, encompassing siRNA polyplexes as well as nanoparticle and micellar formulations for hydrophobic drugs. Special emphasis is placed on advanced polymerization techniques that allow fine control over molecular weight, charge density, and amphiphilicity. Through rational monomer design and controlled polymerization strategies, polymers are generated that self-assemble into well-defined nanostructures with tunable interactions with the vitreous body and retinal layers.
Selected examples illustrate how polymerization method, macromolecular structure, and formulation strategy collectively direct physicochemical properties, biological performance, and delivery efficiency. In vitro and ex vivo studies using ocular model systems and porcine eyes, which mimic intravitreal and subretinal injection scenarios, demonstrate the potential of these tailor-made polymeric nanoparticles as versatile platforms for delivering diverse active pharmaceutical ingredients. Applications targeting age-related macular degeneration via siRNA-mediated modulation of VEGF and NF-κB levels, as well as nanoparticulate formulations of dexamethasone for the treatment of retinal inflammation, are highlighted.