Chair of Physical Chemistry II (Material and Biophotonic)
The research of the working group focuses mainly on the development and application of innovative Raman-based methods to answer biomedical questions. Raman spectroscopy and the various Raman-based technologies such as Raman microscopy, SERS or CARS are powerful tools for addressing a broad range of bioanalytical and biomedical problems such as the rapid identification of pathogens, the sensitive monitoring of low-concentration molecules (e.g. drugs or metabolites) or the objective clinical evaluation of cell and tissue samples for early cancer detection.
Raman spectra comparison: cautions and pitfalls of similarity metrics
Year of publicationStatusReview pendingPublished in:Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
S. Mostafapour, A. Mokari, S. Guo, J. Popp, T. Bocklitz
Multiplex electrochemical aptasensor for the simultaneous detection of linomycin and neomycin antibiotics
Year of publicationPublished in:Talanta: the international journal of pure and applied analytical chemistry
W. Al borhani, A. Rhouati, D. Cialla-May, J. Popp, M. Zourob
A multiplexing immunosensing platform for the simultaneous detection of snake and scorpion venoms: Towards a better management of antidote administration
Year of publicationPublished in:Talanta: the international journal of pure and applied analytical chemistry
A. AlMusharraf, A. Rhouati, D. Cialla-May, J. Popp, M. Zourob
Development of a label-free, functional, molecular and structural imaging system combining optical coherence tomography and Raman spectroscopy for in vivo measurement of rat retina
Year of publicationPublished in:Biomedical Optics Express
R. Sentosa, M. Salas, C. Merkle, M. Eibl, W. de Jong, A. Amelink, M. Schmitt, I. Krestnikov, V. Shynkar, M. Kempe, T. Schmoll, B. Baumann, M. Andreana, A. Unterhuber, J. Popp, W. Drexler, R. Leitgeb
In vivo access to molecular information of retinal tissue is considered to play a critical role in enabling early diagnosis of ophthalmic and neurodegenerative diseases. The current gold standard of retina imaging, optical coherence tomography and angiography provides only the retinal morphology and blood perfusion, missing the full spectrum of molecular information. Raman spectroscopy addresses this gap while keeping the investigation non-invasive and label-free. Although previous studies have demonstrated the huge diagnostic potential of combining both modalities for in vivo biological tissue measurement, some have either employed unsafe optical power levels for in vivo retinal measurements or presented results that were negative or contradictory. In this study, we have developed an eye-safe multimodal in vivo label-free imaging system and demonstrate the potential of this device by investigating the retina of a living albino rat. The acquired Raman spectra showed relevant Raman bands in comparison with the previous ex vivo studies. Using this multimodal imaging system for non-invasive retina measurements of transgenic rodents holds the potential to advance the understanding of the pathophysiology of both ophthalmic and neurodegenerative diseases.
Characterization of Pro-Drug Metabolism and Drug Permeability Kinetics in a Microphysiological In Vitro Model of the Human Small Intestinal Barrier Incorporating Mucus-Generating Cells Coupled with LC-MS/MS Analysis
Year of publicationPublished in:Advanced Healthcare Materials
S. AlShmmari, R. Fardous, M. ALHamamah, D. Cialla-May, J. Popp, Q. Ramadan, M. Zourob
Year of publicationPublished in:Journal of Biophotonics
F. Baldini, K. Dholakia, P. French, O. Guntinas-Lichius, A. Kohler, W. Mäntele, L. Marcu, R. Sroka, S. Umapathy, J. Popp